No. 5 USC is set to take on No. 16 Washington State on Friday, while No. 2 Clemson travels to Blacksburg on Saturday for yet another primetime game against an undefeated ACC opponent: No. 12 Virginia Tech.
WEEK 5 PICKS: Straight up | Against the spread
Elsewhere, No. 24 Mississippi State is set to match up with No. 13 Auburn, and No. 15 Oklahoma St. will look to rebound from last week’s loss against TCU when it faces undefeated Texas Tech.
Here’s how you can watch every AP Top 25 team in action this week (all times Eastern) .